Nitric oxide as a mediator of inflammation?--You had better believe it
1995
Nitric Oxide and Inflammation
publication
Evidence: moderate
Author Information
Author(s): Mark J. S. Miller, Matthew B. Grisham
Primary Institution: Louisiana State University Medical Center
Hypothesis
Nitric oxide plays a significant role in inflammation and its effects can vary based on several factors.
Conclusion
Nitric oxide is primarily a pro-inflammatory mediator in chronic inflammation and can contribute to tissue injury.
Supporting Evidence
- Nitric oxide is linked to increased cancer incidence in chronic inflammation.
- Inhibition of inducible nitric oxide synthase can provide therapeutic benefits.
- Excess nitric oxide production can lead to tissue injury.
- Different cellular sources of nitric oxide can influence its effects in inflammation.
Takeaway
Nitric oxide can help in small amounts but too much can hurt us, especially when we are sick.
Limitations
The study lacks solid evidence for the protective effects of nitric oxide synthase inhibition in human diseases.
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