Hemostasis and Ageing
Author Information
Author(s): Mari Daniela, Ogliari Giulia, Castaldi Davide, Vitale Giovanni, Bollini Elisa Mariadele, Lio Domenico
Primary Institution: Dipartimento di Scienze Mediche e U.O. di Geriatria, IRCCS, Istituto Auxologico Italiano, Università di Milano, Milano, Italy
Hypothesis
Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment.
Conclusion
The study suggests that the state of hypercoagulability and the possession of several high-risk alleles may be compatible with longevity and health in centenarians.
Supporting Evidence
- Centenarians have a state of hypercoagulability with high coagulation enzyme activity.
- Parameters considered risk factors for atherosclerotic diseases may lose their significance in advanced age.
- The study found that centenarians possess several high-risk genetic markers but still achieve longevity.
Takeaway
As people get older, their blood can become stickier, which might help them live longer, even if they have some genes that usually increase health risks.
Methodology
The study measured parameters of coagulation and fibrinolysis in centenarians and compared them with younger and older controls.
Participant Demographics
The study included 336 participants with a mean age of 77 years, 47% of whom were female.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 02–1.9 years
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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