Synthetic Efforts for Determining the Structure of Anticancer Compounds from Marine Sources
Author Information
Author(s): Usami Yoshihide, Ichikawa Hayato, Arimoto Masao
Primary Institution: Osaka University of Pharmaceutical Sciences
Hypothesis
Can the stereo structures of pericosines, metabolites from the fungus Periconia byssoides, be determined through total synthesis?
Conclusion
Pericosines show significant cytotoxicity against leukemia cells and are promising candidates for anticancer drug development.
Supporting Evidence
- Pericosines exhibit significant in vitro cytotoxicity against P388 lymphocytic leukemia cells.
- Pericosine A shows the most potent activity and significant in vivo antitumor activity.
- Total syntheses of pericosines are required to confirm their stereo structures.
Takeaway
Scientists are trying to figure out the structure of special compounds from a sea creature that can help fight cancer. They are making these compounds in the lab to understand them better.
Methodology
The review surveys synthetic efforts to produce pericosines and analogues from shikimic acid or quinic acid, including various total synthesis approaches.
Limitations
Determining the stereo structures of pericosines is challenging due to their complex multi-functionalized structures.
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