The FERM and PDZ Domain-Containing Protein Tyrosine Phosphatases, PTPN4 and PTPN3, Are Both Dispensable for T Cell Receptor Signal Transduction
2008
The Role of PTPN3 and PTPN4 in T Cell Receptor Signal Transduction
publication
Evidence: high
Author Information
Author(s): Timothy J. Bauler, Wiljan J. A. J. Hendriks, Philip D. King
Primary Institution: University of Michigan Medical School
Hypothesis
PTPN3 and PTPN4 may function redundantly in T cell receptor signal transduction.
Conclusion
PTPN3 and PTPN4 are not necessary for T cell receptor signal transduction, as their absence does not affect T cell development or function.
Supporting Evidence
- PTPN3-deficient mice show normal T cell function.
- PTPN4-deficient mice also exhibit normal T cell development.
- Double-deficient mice for PTPN3 and PTPN4 have no T cell phenotype.
- Triple-deficient mice lacking PTPN3, PTPN4, and PTPN13 show normal T cell responses.
Takeaway
The study found that two proteins, PTPN3 and PTPN4, are not needed for T cells to work properly, even when they are both missing.
Methodology
The study involved generating and analyzing various genetically modified mice to assess T cell development and function.
Limitations
The study may not account for potential compensatory mechanisms from other phosphatases.
Digital Object Identifier (DOI)
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