Effects of Somatostatin on Cytotoxins from Blood Cells
Author Information
Author(s): S. Yousefi, N. Vaziri, G. Carandang, W. Le, R. Yamamoto, G. Granger, J. Ocariz, T. Cesario
Primary Institution: University of California Irvine
Hypothesis
Can somatostatin influence the production and bioactivity of cytotoxins from human peripheral blood mononuclear cells?
Conclusion
Certain forms of somatostatin can enhance the bioactivity of cytotoxins while decreasing their production.
Supporting Evidence
- The 28 amino acid form of somatostatin significantly enhanced the bioactivity of lymphotoxin and tumor necrosis factor.
- The 14 amino acid form of somatostatin enhanced lymphotoxin activity but not tumor necrosis factor activity.
- The naturally occurring 14 amino acid form of somatostatin significantly diminished the production of cytotoxin by human peripheral blood mononuclear cells.
Takeaway
Somatostatin can help some immune cells work better but can also stop them from making enough of the substances that fight tumors.
Methodology
The study tested the effects of different forms of somatostatin on the bioactivity of lymphotoxin and tumor necrosis factor using human peripheral blood mononuclear cells.
Limitations
The study may not fully represent in vivo conditions as it was conducted in vitro.
Participant Demographics
Normal human donors provided the peripheral blood mononuclear cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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