Cognitive Effects of Deep Brain Stimulation Surgery in Parkinson's Disease
Author Information
Author(s): Munoz Miranda J., Arora Rishabh, Rivera Yessenia M., Drane Quentin H., Pal Gian D., Verhagen Metman Leo, Sani Sepehr B., Rosenow Joshua M., Goelz Lisa C., Corcos Daniel M., David Fabian J.
Primary Institution: Northwestern University
Hypothesis
Does subthalamic nucleus deep brain stimulation surgery affect cognitive aspects of motor control in Parkinson's disease?
Conclusion
The study found that saccade latency and reach reaction time significantly increased after surgery compared to before surgery.
Supporting Evidence
- Saccade latency increased by 38% post-surgery.
- Reach reaction time increased by 20% post-surgery.
- Participants were tested while off medication and off deep brain stimulation.
Takeaway
After surgery for Parkinson's disease, it took longer for patients to move their eyes and reach for things when they weren't on medication.
Methodology
Participants were tested on saccade latency and reach reaction time before and after surgery while off medication.
Potential Biases
Potential variability in individual responses to surgery and medication.
Limitations
The study had a small sample size and high variability in participant performance.
Participant Demographics
Participants were individuals with Parkinson's disease, average age 66 years.
Statistical Information
P-Value
< 0.001
Confidence Interval
95% CI: 0.18 to 0.46 for saccade latency; 95% CI: 0.09 to 0.28 for reach RT
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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