A randomized trial to assess the impact of opinion leader endorsed evidence summaries on the use of secondary prevention strategies in patients with coronary artery disease: the ESP-CAD trial protocol
2006

Impact of Opinion Leaders on Heart Disease Treatment

Sample size: 480 publication Evidence: moderate

Author Information

Author(s): Finlay A McAlister, Miriam Fradette, Michelle Graham, Sumit R Majumdar, William A Ghali, Randall Williams, Ross T Tsuyuki, James McMeekin, Jeremy Grimshaw, Merril L Knudtson

Primary Institution: University of Alberta

Hypothesis

Does a local opinion leader-based quality improvement intervention influence primary care physicians to increase the provision of secondary prevention therapies in their patients with known CAD compared to usual care?

Conclusion

The study aims to evaluate whether interventions endorsed by local opinion leaders can improve the use of secondary prevention strategies in patients with coronary artery disease.

Supporting Evidence

  • The study will use a cluster randomization design to avoid contamination.
  • The primary outcome is improvement in statin management within six months post-catheterization.
  • Secondary outcomes include the use of other medications like ACE inhibitors and beta-blockers.

Takeaway

This study is trying to see if getting advice from respected doctors can help other doctors give better care to heart patients.

Methodology

Randomized trial testing three different interventions: usual care, Local Opinion Leader Statement, and Unsigned Evidence Statement.

Potential Biases

Potential for bias in the selection of local opinion leaders and their influence on practice.

Limitations

The study may not be powered to detect differences in clinical events over a short timeframe.

Participant Demographics

Patients with coronary artery disease undergoing cardiac catheterization in Alberta, Canada.

Statistical Information

P-Value

p<0.05

Digital Object Identifier (DOI)

10.1186/1748-5908-1-11

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