Antihistaminic Effect of Bauhinia racemosa Leaves
Author Information
Author(s): Nirmal SA, Laware RB, Rathi R, Dhasade VV, Kuchekar BS
Primary Institution: Pravara Rural College of Pharmacy, Loni, India
Hypothesis
The study aims to validate the traditional use of Bauhinia racemosa leaves in treating asthma by assessing their antihistaminic activity.
Conclusion
The ethanol extract of Bauhinia racemosa leaves has significant antihistaminic activity, inhibiting clonidine-induced catalepsy in mice.
Supporting Evidence
- The ethanol extract inhibits clonidine-induced catalepsy but has no effect on haloperidol-induced catalepsy.
- The study suggests that the inhibition is through an antihistaminic action.
- The polar constituents in the ethanol extract may be responsible for the antihistaminic activity.
Takeaway
This study found that a plant called Bauhinia racemosa can help stop a certain type of muscle stiffness in mice, which might help treat asthma.
Methodology
The study used Swiss albino mice to test the effects of an ethanol extract of Bauhinia racemosa on clonidine and haloperidol-induced catalepsy.
Participant Demographics
Male albino mice (Swiss strain) weighing 22-25 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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