Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours
1999
Study of MEN1 Gene in Pituitary Tumors
Sample size: 23
publication
Evidence: moderate
Author Information
Author(s): Farrell W E, Simpson D J, Bicknell J, Magnay J L, Kyrodimou E, Thakker R V, Clayton R N
Primary Institution: Centre for Cell and Molecular Medicine, University of Keele
Hypothesis
What is the role of the MEN1 gene in sporadic pituitary tumors?
Conclusion
The study suggests that gene silencing is unlikely to be a mechanism in sporadic pituitary tumorigenesis.
Supporting Evidence
- The majority of pituitary tumors are monoclonal in origin.
- Five of 20 tumors showed loss of heterozygosity telomeric to the menin gene.
- No mutations were found in any of the 23 tumors studied.
Takeaway
Researchers looked at a gene called MEN1 in pituitary tumors and found that it likely doesn't cause these tumors to form.
Methodology
The study involved sequence analysis of MEN1 coding exons and flanking intronic sequences in tumors and matched patient leucocyte DNA.
Limitations
The study did not find mutations in the MEN1 gene in the tumors analyzed.
Digital Object Identifier (DOI)
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