Bamboo Extract Reduces Inflammatory Markers in Skin Cells
Author Information
Author(s): Qi Xu-Feng, Kim Dong-Heui, Yoon Yang-Suk, Song Soon-Bong, Teng Yung-Chien, Cai Dong-Qing, Lee Kyu-Jae
Primary Institution: Key Laboratory for Regenerative Medicine, Ministry of Education, Jinan University
Hypothesis
The potential antioxidant effects of Bambusae caulis in Liquamen (BCL) might suppress the production of thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in human keratinocytes.
Conclusion
BCL significantly suppressed IFN-γ-induced expression of TARC and MDC by inhibiting the activation of ROS/IκB/NF-κB pathways.
Supporting Evidence
- BCL suppressed IFN-γ-stimulated TARC release in a dose-dependent manner.
- BCL significantly blocked IFN-γ-induced degradation of IκB-α.
- BCL inhibited the activation of NF-κB in HaCaT cells.
Takeaway
Bamboo extract can help reduce inflammation in skin cells, which might be useful for treating skin conditions like eczema.
Methodology
The study used human keratinocyte cells (HaCaT) to assess the effects of BCL on TARC and MDC expression through various assays including ELISA and Western blotting.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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