Serum FOXM1 and IGF2 Levels in ARDS Patients
Author Information
Author(s): Liu Chao, Zhang Shengrui, Zhang Weiwei, Wang Jinfeng
Primary Institution: Ganzhou People’s Hospital
Hypothesis
The study investigates the relationship between serum FOXM1 and IGF2 levels in ARDS patients and their correlation with disease severity and prognosis.
Conclusion
Serum FOXM1 and IGF2 mRNA levels in ARDS patients are correlated with the severity and prognosis of the disease.
Supporting Evidence
- FOXM1 mRNA levels decreased with disease severity in ARDS patients.
- IGF2 mRNA levels increased as ARDS patients' condition worsened.
- Logistic regression identified FOXM1 and IGF2 as significant prognostic factors for ARDS.
Takeaway
This study found that patients with ARDS have lower levels of FOXM1 and higher levels of IGF2 in their blood, which can help doctors understand how severe their condition is.
Methodology
The study involved measuring serum levels of FOXM1 and IGF2 mRNA in ARDS patients and comparing them with healthy controls, along with logistic regression analysis to identify prognostic factors.
Potential Biases
The study may have bias due to its retrospective design and single-center data collection.
Limitations
The study was conducted at a single center, which may limit the generalizability of the results.
Participant Demographics
The ARDS group included 190 patients (105 males, 85 females) aged 30–70 years.
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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