Improving Famotidine Delivery with Spanlastic Nano-Vesicles
Author Information
Author(s): Almohamady Hend I., Mortagi Yasmin, Gad Shadeed, Zaitone Sawsan, Alshaman Reem, Alattar Abdullah, Alanazi Fawaz E., Hanna Pierre A.
Primary Institution: Department of Pharmaceutics, Faculty of Pharmacy, Sinai University, Egypt
Hypothesis
This study aimed to better understand factors affecting the physicochemical properties of spanlastics and use them to enhance the bioavailability of famotidine.
Conclusion
Spanlastics improved famotidine dissolution, drug release characteristics, membrane permeation, and pharmacokinetic behavior.
Supporting Evidence
- Spanlastics showed enhanced Cmax, AUC0–24, and bioavailability.
- The optimal spanlastic formulation exhibited small particle size (<200 nm) and appropriate polydispersity index (<0.4).
- The entrapment efficiency and drug loading of the optimum formula assured its suitability for hydrophobic drug entrapment.
Takeaway
Researchers created tiny carriers called spanlastics to help a medicine called famotidine dissolve better and work faster in the body.
Methodology
Famotidine was incorporated into nano-spanlastics using the ethanol injection method, Box–Behnken design, and mathematical modeling.
Limitations
The safety of spanlastic administration via different routes was not properly addressed.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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