HER-2/neu Expression in Oesophageal Cancer
Author Information
Author(s): K. Mimura, K. Kono, M. Hanawa, F. Mitsui, H. Sugai, N. Miyagawa, A. Ooi, H. Fujii
Primary Institution: University of Yamanashi
Hypothesis
The study aims to clarify the frequencies of HER-2 expression and gene amplification in patients with oesophageal squamous cell carcinoma and evaluate the relationship between HER-2 status and HLA haplotype.
Conclusion
The study found that HER-2-positive tumours were present in 30.3% of patients, and those with HER-2 gene amplification had a significantly worse survival rate.
Supporting Evidence
- 30.3% of patients had HER-2-positive tumours.
- 11.0% of patients showed HER-2 gene amplification.
- Survival rates were significantly worse in patients with HER-2 positivity and gene amplification.
Takeaway
This study looked at how often a specific protein called HER-2 is found in a type of throat cancer and how it affects patient survival.
Methodology
The study used immunohistochemistry and fluorescence in situ hybridisation to determine HER-2 expression and gene amplification in oesophageal SCC.
Limitations
The sample size is limited, which may affect the validity of the conclusions.
Participant Demographics
{"mean_age":65.3,"gender_distribution":{"male":62,"female":4}}
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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