Geminin-Deficient Neural Stem Cells Exhibit Normal Cell Division and Normal Neurogenesis
2011
Geminin-Deficient Neural Stem Cells Exhibit Normal Cell Division and Normal Neurogenesis
publication
Evidence: high
Author Information
Author(s): Kathryn M. Schultz, Ghazal Banisadr, Ruben O. Lastra, Tammy McGuire, John A. Kessler, Richard J. Miller, Thomas J. McGarry
Primary Institution: Northwestern University Feinberg School of Medicine
Hypothesis
Is Geminin necessary for neurogenesis in neural stem cells?
Conclusion
Geminin is largely dispensable for most of embryonic and adult mammalian neurogenesis.
Supporting Evidence
- Neural-specific GmnnΔ/Δ mice are viable and fertile.
- They display no obvious neurological or neuroanatomical abnormalities.
- GmnnΔ/Δ NSCs give rise to normal numbers of mature neurons.
- The growth rate and cell cycle distribution of cultured GmnnΔ/Δ neurosphere cells are indistinguishable from controls.
Takeaway
The study found that even without a protein called Geminin, brain cells can still grow and develop normally.
Methodology
The researchers created a strain of mice with the Geminin gene deleted from neural stem cells and observed their development and neurogenesis.
Limitations
The study may not account for very early neural induction effects of Geminin.
Digital Object Identifier (DOI)
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