TCF7L2 Gene Variant and Type 2 Diabetes Risk in Brazil
Author Information
Author(s): Marquezine GF, Pereira AC, Sousa AGP, Mill JG, Hueb WA, Krieger JE
Primary Institution: Heart Institute, University of São Paulo Medical School
Hypothesis
Does the TCF7L2 polymorphism rs7903146 affect diabetes risk in the Brazilian population?
Conclusion
The TCF7L2 rs7903146 T allele is associated with an increased risk for type 2 diabetes in a Brazilian cohort, but it does not improve diabetes risk prediction tools.
Supporting Evidence
- TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes.
- The addition of the TCF7L2 polymorphism to a diabetes risk prediction tool did not improve its accuracy.
- This study is the first to confirm the association of TCF7L2 with diabetes in a South American population.
- Genotyping was performed on a total of 2009 individuals across two different populations.
Takeaway
A specific gene variant can increase the risk of getting diabetes, but adding it to existing risk prediction tools doesn't make them better.
Methodology
Genotyping of the TCF7L2 gene variant rs7903146 was performed in two populations: 560 patients with coronary disease and 1,449 residents from Vitoria, Brazil.
Limitations
The study's findings may be limited by the low prevalence of diabetes in the general population sample, affecting statistical power.
Participant Demographics
The MASS II population had a male preponderance (69.1%) and a high diabetes prevalence of 31.0%. The general population sample had a mean age of 44.8 years and a diabetes prevalence of 7.9%.
Statistical Information
P-Value
0.0032
Confidence Interval
95%CI 1.16–2.11
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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