Nature-Based Gel for Gingivitis Treatment
Author Information
Author(s): Figueiredo Luciene Cristina, Bueno-Silva Bruno, Denúncio Giovanna, Figueiredo Nathalia Freitas, da Cruz Daniele Ferreira, Shibli Jamil A., Borges Maria Helena R., Barão Valentim A. R., Haim Doron, Asbi Thabet
Primary Institution: Guarulhos University
Hypothesis
Does a nature-based gel effectively control gingival inflammation and alter the proteomic profile of gingival crevicular fluid compared to conventional toothpaste?
Conclusion
The nature-based gel achieved similar clinical outcomes to conventional toothpaste in controlling gingival inflammation but significantly altered the proteomic profile of gingival crevicular fluid.
Supporting Evidence
- The study identified 480 proteins across all groups.
- Both groups showed similar clinical benefits after 3 months.
- The nature-based gel group had 78 exclusive proteins related to immune processes.
- The conventional toothpaste group had 21 exclusive proteins mainly involved in wound healing.
- Participants reported full adherence to the oral hygiene protocol.
- No adverse effects were detected during the study.
- Clinical parameters showed no significant differences between the two groups.
Takeaway
A special gel made from natural ingredients works just as well as regular toothpaste for gum health, but it changes the proteins found in the mouth in a unique way.
Methodology
This was a double-blind, parallel, randomized, and controlled clinical trial comparing a nature-based gel and conventional toothpaste over 3 months.
Potential Biases
Potential bias due to the involvement of authors employed by a company related to the study.
Limitations
The sample size may have limited the ability to detect differences between the groups, and longer follow-up periods are needed to assess the maintenance of outcomes.
Participant Demographics
20 participants, aged 18-65, with gingivitis; 8 women and 2 men in the nature-based gel group, 7 women and 3 men in the control group.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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