Effects of Fasting on Inflammatory Biomarkers in Older Adults
Author Information
Author(s): Engeland Christopher, Tennyson Robert, Wright Molly, Knight Erik, Mousavi Seyedeh Leila, Buxton Orfeu, Graham-Engeland Jennifer
Primary Institution: The Pennsylvania State University
Hypothesis
What are the effects of fasting status on blood-based biomarker concentrations in older adults?
Conclusion
Fasting does not affect basal inflammation levels, but eating decreases stimulated TNF-α levels.
Supporting Evidence
- Fasting did not change levels of basal cytokines, CRP, or suPAR.
- Eating decreased stimulated TNF-α levels after 2h and 24h incubation.
- There was weak evidence that eating decreased stimulated IL-6 after 2h incubation.
Takeaway
When older people fast, their inflammation levels stay the same, but eating can lower certain inflammation markers.
Methodology
Older adults fasted before two lab visits with blood draws to compare fasting and post-meal effects on biomarkers.
Limitations
Further research is needed for stimulated IL-6, which showed uncertain evidence of change.
Participant Demographics
30 older adults with an average age of 67.52; 70% women.
Digital Object Identifier (DOI)
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