Full dose chemotherapy in elderly patients with non-Hodgkin's lymphoma: a feasibility study using a mitoxantrone containing regimen
1990
Full Dose Chemotherapy in Elderly Patients with Non-Hodgkin's Lymphoma
Sample size: 30
publication
Evidence: moderate
Author Information
Author(s): P. Sonneveld, J.J. Michiels
Primary Institution: University Hospital Rotterdam Dijkzigt
Hypothesis
Is full dose chemotherapy feasible for elderly patients with non-Hodgkin's lymphoma?
Conclusion
Full dose CNOP chemotherapy is feasible for elderly patients with non-Hodgkin's lymphoma and does not result in major toxicity.
Supporting Evidence
- 60% of patients achieved a complete response.
- 90% of patients had a total response rate.
- Only two serious infections were noted during treatment.
Takeaway
Doctors tested a strong cancer treatment on older patients and found it worked well without causing serious side effects.
Methodology
A prospective study evaluating the feasibility of full dose chemotherapy in elderly patients with non-Hodgkin's lymphoma using a CNOP regimen.
Limitations
The study had a small sample size and a short follow-up period.
Participant Demographics
30 patients, mean age 70.4 years, 9 male and 21 female.
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