Rapid Dipstick Test for Schistosomiasis Japonica
Author Information
Author(s): Yu Li-Ling, Ding Jian-Zu, Wen Li-Yong, Lou Di, Yan Xiao-Lan, Lin Li-Jun, Lu Shao-Hong, Lin Dan-Dan, Zhou Xiao-Nong
Primary Institution: Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou, China
Hypothesis
Can a new rapid dipstick test effectively diagnose schistosomiasis japonica?
Conclusion
The DLIA is a simple, rapid, and effective assay for diagnosing schistosomiasis japonica, suitable for large-scale applications.
Supporting Evidence
- The sensitivity of DLIA was 95.10% and specificity was 94.91%.
- DLIA showed no significant difference in detection rates compared to ELISA.
- The kappa value between DLIA and ELISA was 0.90, indicating high agreement.
- Field tests involved 333 serum samples from an endemic area.
Takeaway
Researchers created a quick test to find out if people have schistosomiasis, which is a disease caused by a parasite. This test is easy to use and can help many people at once.
Methodology
The study developed a dipstick test using latex microspheres to detect antibodies in human serum, comparing results with ELISA and Kato-Katz methods.
Limitations
The study did not address the cross-reactivity with paragonimiasis and the potential for false positives.
Participant Demographics
Participants were aged 6-65 years from a schistosomiasis endemic area in Jiangxi Province, China.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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