Gene Variants Linked to Diabetes and Kidney Problems in Asian Indians
Author Information
Author(s): Prasad Pushplata, Tiwari Arun K, Kumar KM Prasanna, Ammini AC, Gupta Arvind, Gupta Rajeev, Thelma BK
Primary Institution: University of Delhi South Campus
Hypothesis
The study tests the association of specific gene polymorphisms with type-2 diabetes and chronic renal insufficiency.
Conclusion
The allele 59029A of the CCR5 gene is significantly associated with diabetic renal insufficiency among Asian Indians.
Supporting Evidence
- The allele 59029A of the CCR5 gene was found to increase the risk of diabetic chronic renal insufficiency.
- A compound genotype of SNP G>A -800 was associated with proliferative retinopathy in diabetic patients.
Takeaway
Some genes can make people more likely to have kidney problems if they have diabetes, especially in Asian Indians.
Methodology
The study used a case-control design to analyze nine SNPs in diabetes patients with and without chronic renal insufficiency.
Limitations
The sample size was sub-optimal for some analyses, warranting replication in larger studies.
Participant Demographics
Participants were Asian Indians with type-2 diabetes, including those with chronic renal insufficiency and normoalbuminuria.
Statistical Information
P-Value
0.035
Confidence Interval
1.04–1.84
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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