PPAR-δ in Vascular Pathophysiology
2008
PPAR-δ in Vascular Pathophysiology
publication
Evidence: moderate
Author Information
Author(s): Nanping Wang
Primary Institution: Peking University Health Science Center
Hypothesis
PPAR-δ may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.
Conclusion
Activation of PPAR-δ may have profound effects on vascular homeostasis and coronary artery diseases.
Supporting Evidence
- PPAR-δ plays direct roles in various basic vascular processes such as apoptosis, survival, angiogenesis, and inflammation.
- PPAR-δ agonists have been shown to improve lipid profiles and have anti-inflammatory effects.
- Studies suggest that PPAR-δ may be a therapeutic target for atherosclerosis.
Takeaway
PPAR-δ is a protein that helps control how our blood vessels work and can be a target for treating heart problems.
Limitations
The efficacy of PPAR-δ agonists in human coronary artery diseases remains to be clarified.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website