Using Breath Measurements to Predict Central Venous Oxygen Saturation
Author Information
Author(s): Jones Alan E, Kuehne Karl, Steuerwald Michael, Kline Jeffrey A
Primary Institution: Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Hypothesis
The partial pressure of expired oxygen in end tidal breaths (EtO2) will correlate with central venous oxygen saturation (ScVO2).
Conclusion
We found no significant correlation between EtO2 and ScVO2.
Supporting Evidence
- The correlation between EtO2 and measured ScVO2 yielded R2 = 0.11.
- The predicted ScVO2 value was within 10% of the actual value for 57% of the patients.
- Modeling of the EtO2 curve did not accurately predict ScVO2 at any lung volume.
Takeaway
The study tried to see if measuring oxygen in breath could help predict how much oxygen is in the blood, but it didn't work well.
Methodology
Prospective observational study of hemodialysis patients using a portable respiratory device to measure breath and blood samples.
Potential Biases
Potential inaccuracies in expired gas measurements due to side-stream sampling.
Limitations
The small sample size and the specific patient population may limit the generalizability of the findings.
Participant Demographics
Average age of 51.4 years, 60% male, all patients were hemodialysis patients.
Statistical Information
P-Value
0.057
Statistical Significance
p=0.057
Digital Object Identifier (DOI)
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