Dietary Protein Restriction Reduces Aging Effects in Mice
Author Information
Author(s): Easter Molly, Young Khristina, Sothers Hanna, Aldridge Jolaiya, Batamack Yvann, Vaddi Prerana, Morrison Christopher D, Hill Cristal
Primary Institution: University of Southern California
Hypothesis
Does dietary protein restriction reduce markers of cellular senescence in adipose tissue during aging and obesity?
Conclusion
Dietary protein restriction significantly reduces markers of cellular senescence in the adipose tissue of aged male mice.
Supporting Evidence
- Mice on a low protein diet showed significant decreases in p21 and SASP markers.
- Low protein diet mice had reduced SA-Bgal staining in adipose tissue.
- Mice on a low protein/high fat diet also showed reduced cellular senescence markers.
Takeaway
Feeding older mice less protein helps their bodies stay healthier by reducing signs of aging in their fat tissue.
Methodology
16 month old male C57BL/6 mice were fed different protein diets for 24 weeks, and adipose tissue was analyzed for cellular senescence markers.
Participant Demographics
16 month old male C57BL/6 mice
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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