Genetic Variation in Folate and Drug Metabolism in South India
Author Information
Author(s): Rai Padmalatha S, Murali T. S, Vasudevan T. G, Prasada Shama K., Bhagavath Ashok Kumar Pai, Pranita Gopinath P. M., Satyamoorthy K.
Primary Institution: Manipal University
Hypothesis
The study aims to quantify the allele frequencies for MTHFD1, TYMS, SHMT1, MTR, MTRR, CBS, and SULT1A1 gene polymorphisms in a south Indian population.
Conclusion
The study reports the frequency distribution of several gene polymorphisms in a south Indian population, highlighting significant differences compared to other populations.
Supporting Evidence
- The study found significant differences in allele frequencies for several SNPs compared to other populations.
- Genotype distributions were analyzed for multiple genes involved in drug metabolism.
- The findings suggest that genetic variations can influence drug response in different populations.
Takeaway
This study looked at how different people's genes can affect how they process medicine, and found that people from South India have unique genetic traits.
Methodology
Genotyping of SNPs was performed using RFLP analysis and confirmed by DNA sequencing.
Potential Biases
Potential population stratification may affect the results.
Limitations
The results should be interpreted with caution due to deviations from Hardy-Weinberg equilibrium in some SNPs.
Participant Demographics
Healthy unrelated south Indian volunteers from different locations.
Statistical Information
P-Value
0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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