α1A-Adrenergic Receptor Induces Activation of Extracellular Signal-Regulated Kinase 1/2 through Endocytic Pathway
2011
How α1A-Adrenergic Receptor Activates ERK1/2 through Endocytosis
publication
Evidence: moderate
Author Information
Author(s): Liu Fei, He Kangmin, Yang Xinxing, Xu Ning, Liang Zhangyi, Xu Ming, Zhao Xinsheng, Han Qide, Zhang Youyi
Primary Institution: Institute of Vascular Medicine, Peking University Third Hospital
Hypothesis
Is endocytosis involved in α1A-adrenergic receptor-induced activation of ERK1/2?
Conclusion
The study concludes that endocytosis is involved in α1A-adrenergic receptor-induced activation of ERK1/2, independent of Gq/PLC/PKC signaling.
Supporting Evidence
- The endocytic pathway is involved in α1A-AR-induced ERK1/2 activation.
- Endocytosis disruption did not affect α1A-AR-induced activation of PKC and C-Raf.
- Actin filaments regulate the initial trafficking of α1A-AR.
Takeaway
This study shows that a specific receptor in our body can send signals to help heart cells survive, and it does this by using a process called endocytosis.
Methodology
Real-time imaging of living HEK-293A cells was used to assess the endocytic traffic of α1A-AR.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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