Evolution of the Holozoan Ribosome Biogenesis Regulon
Author Information
Author(s): Seth J Brown, Michael D Cole, Albert J Erives
Primary Institution: Dartmouth Medical School
Hypothesis
How is the ribosome biogenesis gene set coordinately regulated in complex metazoan genomes?
Conclusion
The study concludes that a Myc regulon, which is activated in proliferating cells, has primordial roots in the evolution of ribosome biogenesis in a protozoan ancestor of animals.
Supporting Evidence
- The ribosome biogenesis genes are co-regulated by a specific E(CG)-bearing promoter architecture.
- 77% of human ribosome biogenesis genes possess an E(CG) motif.
- The E(CG) signature is absent in nematode genomes, indicating a secondary loss.
Takeaway
This study found that a specific set of genes that help make ribosomes evolved together with a protein called Myc in early ancestors of animals.
Methodology
The study used a multi-genomic approach to analyze ribosome biogenesis genes across various eukaryotic genomes.
Limitations
The study does not address the regulatory mechanisms in organisms lacking Myc.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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