Factor VII Gene Polymorphism and Cardiovascular Risk in Familial Hypercholesterolemia
Author Information
Author(s): Criado-García Juan, Fuentes Francisco, Cruz-Teno Cristina, García-Rios Antonio, Jiménez-Morales Anabel, Delgado-Lista Javier, Mata Pedro, Alonso Rodrigo, López-Miranda José, Pérez-Jiménez Francisco
Primary Institution: Lipids and Atherosclerosis Unit, Department of Medicine, IMIBIC/Hospital Universitario Reina Sofía/Universidad de Córdoba, Córdoba, Spain
Hypothesis
Does the R353Q polymorphism of the factor VII gene predict cardiovascular risk in patients with Heterozygous Familial Hypercholesterolemia?
Conclusion
The study found no direct relationship between cardiovascular risk in patients with Heterozygous Familial Hypercholesterolemia, the R353Q polymorphism of factor VII, and FVII Ag levels.
Supporting Evidence
- 75% of patients with FH were RR genotype.
- No significant differences in genotype distribution between FH patients and controls.
- 14.7% of FH patients experienced cardiovascular events.
- FVII Ag levels showed no significant differences between FH patients and controls.
Takeaway
This study looked at whether a specific gene change affects heart disease risk in people with a genetic cholesterol problem, and it found that it doesn't.
Methodology
A case-control study comparing 546 patients with Heterozygous Familial Hypercholesterolemia to 174 controls, analyzing genotype distribution and plasma factor VII levels.
Limitations
The study may have been limited by the low number of cardiovascular events in the FH patients.
Participant Demographics
546 patients with Heterozygous Familial Hypercholesterolemia and 174 controls, with a mean age of 43.5 years.
Statistical Information
P-Value
p = 0.32
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website