Adherence to Antiretroviral Therapy in Children with HIV in Eastern and Southern Africa
Author Information
Author(s): Alemu Gebrie Getu, Yirsaw Bantie Getnet, Tesfie Tigabu Kidie, Yismaw Getaneh Awoke, Abuhay Habtamu Wagnew, Alemayehu Meron Asmamaw, Agimas Muluken Chanie, Derseh Nebiyu Mekonnen
Primary Institution: Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
Hypothesis
What is the pooled prevalence of adherence to antiretroviral therapy and its associated factors among children living with HIV in Eastern and Southern Africa?
Conclusion
The pooled prevalence of adherence to antiretroviral therapy among children living with HIV is low, highlighting the need for improved support systems.
Supporting Evidence
- The pooled prevalence of adherence to antiretroviral therapy was found to be 76.2%.
- Factors such as being a biological caregiver and receiving first-line antiretroviral treatment were associated with higher adherence.
- Significant heterogeneity was observed among the included studies.
Takeaway
Many kids with HIV in Eastern and Southern Africa have trouble sticking to their medicine, which is really important for their health.
Methodology
A systematic review and meta-analysis were conducted, analyzing data from 29 studies using a random-effects model.
Potential Biases
The study may be subject to bias due to reliance on caregiver self-reports for adherence.
Limitations
Variations in definitions of adherence and potential publication bias may affect the results.
Participant Demographics
Children living with HIV in Eastern and Southern Africa, with studies conducted in various countries including Ethiopia, Kenya, and South Africa.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 71.4, 81.1
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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