Reply to the letter from Dr Remvikos
1993
Response to Dr. Remvikos on DNA Ploidy and Prognostic Significance
Editorial
Author Information
Author(s): P.D. Stanton, T.G. Cooke
Primary Institution: Department of Surgery, Royal Infirmary
Conclusion
The authors argue that DNA ploidy and S phase fraction do not show independent prognostic significance in their study.
Supporting Evidence
- The authors state that neither DNA ploidy nor S phase fraction showed independent prognostic significance.
- The observed survival difference between groups defined by the median is small, around 10% at 10 years.
- The authors question the relevance of thymidine labelling data from different studies.
Takeaway
The study suggests that measuring certain tumor characteristics may not help predict patient outcomes as previously thought.
Potential Biases
The authors express concern about overenthusiastic acceptance of certain prognostic factors by other researchers.
Limitations
The authors note the potential for type II statistical error and the small survival difference observed.
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