Skin Exposure to Isocyanates: Reasons for Concern
Author Information
Author(s): Dhimiter Bello, Christina A. Herrick, Thomas J. Smith, Susan R. Woskie, Robert P. Streicher, Mark R. Cullen, Youcheng Liu, Carrie A. Redlich
Primary Institution: Harvard School of Public Health
Hypothesis
Does skin exposure to isocyanates contribute to the development of isocyanate asthma?
Conclusion
Sufficient evidence exists to justify greater emphasis on the potential risks of isocyanate skin exposure and the importance of preventing such exposures.
Supporting Evidence
- Isocyanate asthma continues to occur in settings with minimal inhalation exposure but opportunity for skin exposure.
- Animal studies show that skin exposure to isocyanates can induce sensitization leading to asthma-like responses.
- Human studies suggest that skin exposure can contribute to the development of isocyanate asthma.
Takeaway
Isocyanates can cause asthma, and skin exposure to these chemicals might be a big problem that people don't realize.
Methodology
The review evaluated published animal and human literature on isocyanate skin exposure and its role in sensitization and asthma.
Limitations
Limited data on the quantification of skin exposure and the effectiveness of protective equipment.
Digital Object Identifier (DOI)
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