Effectiveness of Clindamycin for Treating Bacterial Vaginosis in Pregnant Women
Author Information
Author(s): Ronald F. Lamont, Brian M. Jones, Debashis Mandal, Philip E. Hay, Marie Sheehan
Primary Institution: Northwick Park and St Mark's NHS Trust
Hypothesis
Is vaginal clindamycin effective in treating bacterial vaginosis during pregnancy?
Conclusion
A 3-day course of clindamycin vaginal cream is more effective than placebo for treating bacterial vaginosis in pregnant women.
Supporting Evidence
- 18% of women treated with clindamycin were cured compared to 1.6% with placebo.
- 70.8% of clindamycin patients showed improvement compared to 12% with placebo.
- 44.8% of clindamycin patients were cured using three diagnostic criteria.
Takeaway
This study shows that a short treatment with clindamycin cream helps pregnant women with a common infection called bacterial vaginosis.
Methodology
A randomized, double-blind, placebo-controlled study involving 404 pregnant women with bacterial vaginosis.
Limitations
The study only included women aged 16 to 40 and may not be generalizable to other populations.
Participant Demographics
Women aged 16 to 40 years, with a live fetus between 13 and 20 weeks gestation.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.0001
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