TAP score: torsion angle propensity normalization applied to local protein structure evaluation
2007
TAP Score: A New Method for Evaluating Protein Structure Quality
Sample size: 13691
publication
Evidence: high
Author Information
Author(s): Tosatto Silvio CE, Battistutta Roberto
Primary Institution: University of Padova, Italy
Hypothesis
Can a new criterion based on torsion angle propensities improve the evaluation of protein model validity?
Conclusion
The TAP score significantly enhances the ability to identify the best experimental protein structures.
Supporting Evidence
- The TAP score was shown to be more accurate than previous methods.
- It recognized over 90% of the top experimental structures without experimental information.
- The study analyzed 13,691 protein structures from the PDB database.
Takeaway
The TAP score helps scientists figure out if a protein's shape is good or needs fixing, making it easier to study proteins.
Methodology
The study introduced the TAP score, which measures local sequence to structure fitness based on normalized torsion angle propensities.
Limitations
The TAP score may overestimate compatibility due to the independence of subsequent residues in normalization.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website