Second Primary Cancers in Men with Breast Cancer
Author Information
Author(s): Hemminki K, Scélo G, Boffetta P, Mellemkjaer L, Tracey E, Andersen A, Brewster D H, Pukkala E, McBride M, Kliewer E V, Chia K-S, Pompe-Kirn V, Martos C, Jonasson J G, Li X, Brennan P
Primary Institution: German Cancer Research Center (DKFZ)
Hypothesis
What is the risk of developing second primary cancers in men who have been diagnosed with breast cancer?
Conclusion
Men with primary breast cancer have a moderate excess risk of developing second primary cancers.
Supporting Evidence
- 12.5% of men with primary breast cancer developed a second neoplasia.
- 34% overall excess risk of second primary neoplasia was observed.
- BRCA2 mutations may explain increased risks for pancreatic and prostate cancers.
Takeaway
If a man has breast cancer, he might get another type of cancer later, but it's not very likely.
Methodology
Data was pooled from 13 cancer registries to analyze the incidence of second primary cancers in men with breast cancer.
Potential Biases
The study relies on data from various cancer registries, which may have different recording practices.
Limitations
The findings may include chance associations due to multiple comparisons.
Participant Demographics
The majority of participants were over 65 years old at diagnosis.
Statistical Information
Confidence Interval
95% CI: 1.35–12.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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