In vitro modelling of epithelial and stromal interactions in non-malignant and malignant prostates
2000
Effects of Cell Interactions on Prostate Cancer
Sample size: 16
publication
Author Information
Author(s): Lang S H, Stower M, Maitland N J
Primary Institution: Yorkshire Cancer Research Unit, Department of Biology, University of York
Hypothesis
How do stromal epithelial cell interactions affect prostate cancer metastasis?
Conclusion
Stromal cells from both malignant and non-malignant tissues similarly influenced epithelial cell growth and invasion in prostate cancer.
Supporting Evidence
- Epithelial cell line growth was similarly unaffected or inhibited by stromal cells from malignant or non-malignant tissue.
- PNT2-C2 and PC-3 cells were the least and most invasive and motile epithelia respectively.
- Stromal cultures enhanced the invasion of both epithelial cells.
Takeaway
The study looked at how different cells in the prostate interact and affect cancer growth, finding that both healthy and unhealthy cells had similar effects.
Methodology
The study used primary human prostatic stromal cells and established epithelial cell lines to assess growth, invasion, and motility through various assays.
Digital Object Identifier (DOI)
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