Planned Abscopal Effect with Pembrolizumab and Radiotherapy: A Case Report
Author Information
Author(s): Lee Yu-Ting, Chen Chien-Chin, Chao Hsiya, Chang Chih-Chia, Lee Cheng-Yen
Primary Institution: Ditmanson Medical Foundation Chiayi Christian Hospital
Hypothesis
Can a planned abscopal effect be induced through concurrent radiotherapy and immunotherapy in a patient with metastatic bladder cancer?
Conclusion
The study demonstrates that a planned abscopal effect can be achieved with concurrent pembrolizumab and ablative radiotherapy in a patient with extensive metastatic bladder cancer.
Supporting Evidence
- The patient achieved complete remission of metastatic tumors after treatment.
- The abscopal effect was planned rather than random, indicating a systematic approach.
- The patient had a combined positive score ≥10, which is associated with better treatment response.
Takeaway
This study shows that using radiation therapy together with a cancer medicine called pembrolizumab can help treat cancer that has spread, even in places that weren't directly treated.
Methodology
The patient received four cycles of pembrolizumab and hypofractionated radiotherapy to selected metastatic lung tumors.
Potential Biases
Inherent bias associated with case reports may affect the reliability of the findings.
Limitations
The findings are based on a single case report, which may not be generalizable.
Participant Demographics
A 53-year-old Asian male with a history of bladder cancer and extensive metastases.
Digital Object Identifier (DOI)
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