The Role of Bile Acid Excretion in Atherosclerotic Coronary Artery Disease
Author Information
Author(s): Gideon Charach, Alexander Rabinovich, Ori Weintraub, Moshe Rabinovich, Pavel Rabinovich
Primary Institution: Tel Aviv Sourasky Medical Center
Hypothesis
Could it be that the inability to efficiently excrete bile acids may lead to CAD development?
Conclusion
The diminished excretion of bile acids might be an independent risk factor for CAD and a potential target for cholesterol lowering treatment.
Supporting Evidence
- CAD patients excreted significantly lower amounts of bile acids compared to healthy individuals.
- Lower excretion of bile acids was associated with advanced atherosclerosis.
- Animal studies showed that efficient bile acid excretion prevents atherosclerosis.
Takeaway
People with heart disease don't get rid of bile acids as well as healthy people, which might make their heart problems worse.
Methodology
The study compared bile acid excretion in CAD patients and healthy controls on the same diet.
Limitations
The study was based on selected populations and may not represent the general population.
Participant Demographics
The study included 36 CAD patients and 37 non-CAD patients.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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