Androstane-3β,5α,6β,17β-tetrol trihydrate C19H32O4·3H2O
2011
Synthesis and Structure of Androstane-3β,5α,6β,17β-tetrol Trihydrate
publication
Evidence: moderate
Author Information
Author(s): Andrade L. C. R., Almeida M. J. B. M., Paixão J. A., Carvalho J. F. S., Sá e Melo M. L.
Primary Institution: University of Coimbra
Hypothesis
The study investigates the synthesis and structural properties of a specific steroid compound.
Conclusion
The synthesized compound exhibits a unique crystal structure with extensive hydrogen bonding.
Supporting Evidence
- The compound was synthesized by stereoselective reduction of 3β,5α,6β-trihydroxyandrostan-17-one.
- X-ray crystallography revealed a unique hydrogen bonding network in the crystal structure.
- Calculated molecular geometry closely matched experimental values, except for certain bond lengths.
Takeaway
Scientists made a new steroid and looked at its structure to understand how it might work in the body.
Methodology
The compound was synthesized using stereoselective reduction and characterized by X-ray crystallography.
Limitations
The absolute configuration of the molecule was not determined due to lack of strong anomalous scatterers.
Digital Object Identifier (DOI)
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