Predicting Relapse in Ulcerative Colitis
Author Information
Author(s): Azad Sheenam, Sood Neena, Sood Ajit
Primary Institution: Dayanand Medical College and Hospital
Hypothesis
Can biological and histological parameters predict relapse in patients with quiescent ulcerative colitis?
Conclusion
Increased eosinophils and neutrophils in the lamina propria can predict a higher risk of relapse in patients with quiescent ulcerative colitis.
Supporting Evidence
- 57.69% of patients had evidence of clinical relapse during the follow-up.
- Hemoglobin, ESR, CRP, and IL-6 levels were not significant predictors of relapse.
- Increased eosinophils and neutrophils in the lamina propria were associated with a higher relapse rate.
Takeaway
Doctors can tell if someone with a quiet case of ulcerative colitis might get sick again by looking at certain cells in their body.
Methodology
A prospective study measuring biological and histological parameters in 26 patients with quiescent ulcerative colitis over one year.
Limitations
Small sample size may limit the generalizability of the findings.
Participant Demographics
15 males and 11 females, ages 15 to 65, with a mean age of 37.61 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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