MicroRNA-10a and MicroRNA-210 as Biomarkers in Sepsis Patients with Acute Kidney Injury
Author Information
Author(s): Susianti Hani, Sutrisnani Catur Suci, Santosa I. P. Adi, Febrianto Wahyu, Kusdjianto Amanda Yuanita, Kuwoyo Kevin Putro, Riyu Elita
Primary Institution: Universitas Brawijaya
Hypothesis
This study investigates the expression of miR-10a-5p and miR-210-3p in sepsis patients with kidney dysfunction (AKI) in the Indonesian population.
Conclusion
The study's findings revealed a significant increase in miR-210-3p expression in sepsis patients with AKI, indicating its potential as a promising biomarker for determining AKI.
Supporting Evidence
- miR-210-3p showed a significant increase in expression in sepsis patients with AKI compared to healthy controls.
- miR-210-3p had a sensitivity of 84.6% and specificity of 63.9% for diagnosing AKI.
- miR-10a-5p did not show significant differences in expression between the groups.
Takeaway
This study looked at two tiny molecules in the blood that might help doctors find kidney problems in sick patients faster. One of them, miR-210-3p, seems to be really good at this job.
Methodology
A cross-sectional study was conducted analyzing microRNA expression using reverse transcription quantitative polymerase chain reaction (RT-qPCR) among sepsis patients with and without AKI and healthy controls.
Limitations
The study had a small number of samples and did not include participants' therapy and comorbidities as variables.
Participant Demographics
Participants were aged 18–65 years, including sepsis patients with and without AKI and healthy controls.
Statistical Information
P-Value
0.013 for miR-210-3p
Confidence Interval
0.652–0.902 for miR-210-3p
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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