Achillea millefolium Protects Kidneys from Doxorubicin Damage in Rats
Author Information
Author(s): SHAIEA Mohammed, DONG Yiming, ALOMAISI Saleh, AL-MAHBASHI Hassan, ZHANG Guozhong, WANG Chuan
Primary Institution: Hebei Medical University
Hypothesis
The study investigates the protective effects of Achillea millefolium extract against doxorubicin-induced nephrotoxicity in rats.
Conclusion
Achillea millefolium extract can protect against kidney damage caused by doxorubicin by reducing oxidative stress and inflammation.
Supporting Evidence
- Doxorubicin caused significant kidney damage, which was reversed by Achillea millefolium extract treatment.
- AME treatment significantly reduced levels of urea, creatinine, and uric acid in rats treated with doxorubicin.
- Histopathological analysis showed that AME restored normal kidney structure in treated rats.
- AME increased antioxidant enzyme activities and decreased oxidative stress markers in kidney tissues.
- AME significantly reduced proinflammatory cytokines in the kidneys of rats treated with doxorubicin.
Takeaway
This study shows that a plant called Achillea millefolium can help protect rat kidneys from damage caused by a cancer medicine called doxorubicin.
Methodology
Rats were divided into six groups and treated with doxorubicin and/or Achillea millefolium extract, followed by biochemical and histopathological analysis.
Limitations
The phytochemical content of Achillea millefolium extract was not examined, and the study used limited experimental methods.
Participant Demographics
Forty-eight mature male rats weighing between 150 and 250 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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