Radioprotection in Mice Using Podophyllum hexandrum Extract
Author Information
Author(s): Sankhwar Sanghmitra, Gupta Manju Lata, Gupta Vanita, Verma Savita, Suri Krishna Avtar, Devi Memita, Sharma Punita, Khan Ehsan Ahmed, Alam M. Sarwar
Primary Institution: Institute of Nuclear Medicine and Allied Sciences
Hypothesis
Can a sub-fraction of Podophyllum hexandrum provide protection against lethal irradiation in mice?
Conclusion
The sub-fraction G-001M from Podophyllum hexandrum significantly increased survival rates and protected cellular DNA in lethally irradiated mice.
Supporting Evidence
- G-001M treatment resulted in over 90% survival in lethally irradiated mice.
- DNA damage was significantly reduced in treated mice compared to controls.
- Thymocyte and splenocyte counts improved in G-001M pre-treated groups over time.
Takeaway
A special extract from a plant called Podophyllum hexandrum can help mice survive better after being exposed to harmful radiation.
Methodology
Mice were treated with G-001M before exposure to lethal gamma radiation, and various biological parameters were measured post-irradiation.
Limitations
The study was conducted only on mice, and results may not directly translate to humans.
Participant Demographics
Swiss albino male mice, 8-10 weeks old.
Statistical Information
P-Value
p<0.001
Confidence Interval
(28.33, 30.25)
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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