Role of Sigma Receptors in Methamphetamine-Induced Neurotoxicity
2011
Role of Sigma Receptors in Methamphetamine-Induced Neurotoxicity
publication
Evidence: moderate
Author Information
Author(s): Kaushal Nidhi Matsumoto Rae R
Primary Institution: West Virginia University
Hypothesis
METH interacts with sigma receptors, which may play a role in its neurotoxic effects.
Conclusion
Sigma receptor antagonists can prevent the neurotoxic effects of methamphetamine in mice.
Supporting Evidence
- Methamphetamine is widely abused and has harmful effects on the brain.
- Sigma receptors are involved in the neurotoxic effects of methamphetamine.
- Blocking sigma receptors can prevent some of the harmful effects of methamphetamine.
Takeaway
Methamphetamine can harm the brain, but blocking certain receptors might help protect it.
Methodology
This review compiles studies from the literature regarding sigma receptors and their role in methamphetamine-induced neurotoxicity.
Limitations
The review does not conduct systematic mechanistic studies in the context of methamphetamine.
Digital Object Identifier (DOI)
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