Effectiveness and Mechanism of Resibufogenin on Human Renal Cancer Cell Caki-1
2024
Resibufogenin's Effect on Kidney Cancer Cells
Sample size: 54
publication
10 minutes
Evidence: high
Author Information
Author(s): Wu Yuqi, Yang Yue, Huang Run, Li Tao, Wan Chunlei, Zhang Lei
Primary Institution: Mudanjiang Normal University
Hypothesis
Resibufogenin can inhibit renal cell carcinoma through multiple targets and pathways.
Conclusion
Resibufogenin effectively inhibits the proliferation and migration of renal cancer cells and induces apoptosis.
Supporting Evidence
- Resibufogenin was shown to significantly inhibit cell migration at a concentration of 10 nM.
- The IC50 value for Resibufogenin on Caki-1 cells was calculated as 408.2 nM.
- Apoptosis rates in Caki-1 cells increased significantly with higher concentrations of Resibufogenin.
- Resibufogenin altered the morphology of Caki-1 cells, indicating its effect on cell structure.
- Gene expression of MAPK1 and PRKCB was significantly reduced in Caki-1 cells treated with Resibufogenin.
Takeaway
This study shows that a substance called Resibufogenin can help fight kidney cancer by stopping cancer cells from growing and moving around.
Methodology
The study used network pharmacology, molecular docking, and in vitro experiments to analyze the effects of Resibufogenin on renal cancer cells.
Statistical Information
P-Value
408.2 nM
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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