DNA Damage Genes and Bladder Cancer Risk
Author Information
Author(s): Choudhury Ananya, Elliott Faye, Iles Mark M, Churchman Michael, Bristow Robert G, Bishop D Timothy, Kiltie Anne E
Primary Institution: Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine
Hypothesis
SNPs in DSB signalling genes may modulate predisposition to bladder cancer and influence the effects of environmental exposures.
Conclusion
Apart from a possible effect for one MRE11 3'UTR SNP, our study does not support the hypothesis that SNPs in DSB signaling genes modulate predisposition to bladder cancer.
Supporting Evidence
- Smoking and occupational dye exposure were strongly associated with bladder cancer risk.
- The MRE11 3'UTR SNP rs2155209 showed a marginal increase in bladder cancer risk.
- No significant interaction was found between SNPs and exposure to smoking or dye exposure.
Takeaway
This study looked at how certain genes related to DNA damage might affect the risk of getting bladder cancer, but found that only one gene variant seemed to have a small effect.
Methodology
The study recruited 771 bladder cancer cases and 800 controls, genotyping 24 SNPs in several DNA damage repair genes.
Potential Biases
Recall bias may have affected the accuracy of self-reported smoking and occupational exposure data.
Limitations
The study was underpowered to detect effects for SNPs with low minor allele frequencies and had issues with Hardy-Weinberg equilibrium in some control groups.
Participant Demographics
The majority of participants were Caucasian, with no significant differences in age or sex between cases and controls.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI (1.13–2.08)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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