Reactions of the Antiarthritic Drug Aurothiomalate with Phenylmercury(II) Compounds: NMR Studies
1996
Reactions of Aurothiomalate with Phenylmercury Compounds
publication
Evidence: moderate
Author Information
Author(s): Garry G. Graham, Diarmaid Gordon, Peter J. Sadler
Primary Institution: School of Physiology and Pharmacology, University of NSW
Hypothesis
How does aurothiomalate interact with phenylmercury compounds?
Conclusion
Aurothiomalate's structure remains largely unchanged when interacting with phenylmercury compounds, but these interactions may affect its antimicrobial efficacy.
Supporting Evidence
- Aurothiomalate is a potent inhibitor of collagenase in the presence of para-hydroxymercuribenzoate.
- The study found that arylmercury complexes do not significantly alter the bulk structure of aurothiomalate.
- NMR spectroscopy showed that the addition of phenylmercury compounds resulted in observable shifts in chemical resonances.
Takeaway
This study looks at how a drug called aurothiomalate interacts with certain mercury compounds, which could change how well the drug works.
Methodology
The interactions were studied using NMR and UV spectroscopy in various pH conditions.
Limitations
The study could not explore reactions at physiological pH values for some compounds.
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