Vitamin D, Gut Microbiota, and Central Precocious Puberty
Author Information
Author(s): Guo Doudou, Ning Xin, Bai Tao, Tan Lingfang, Zhou Yanfen, Guo Zhichen, Li Xin
Primary Institution: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Hypothesis
This review aims to clarify the effect of vitamin D deficiency on the occurrence and development of central precocious puberty (CPP) and explore the role of gut microbiota in it.
Conclusion
Vitamin D supplementation and gut microbiota interventions offer a promising, non-invasive strategy for managing central precocious puberty.
Supporting Evidence
- Vitamin D plays a crucial role in children's growth and development, maintaining calcium homeostasis, promoting bone growth, and regulating neuroendocrine and reproductive functions.
- Vitamin D deficiency is associated with various health issues, including immune dysfunction, obesity, metabolic syndrome, infections, cancer, and cardiovascular diseases.
- Recent studies highlight a potential link between precocious puberty, vitamin D, gut microbiota, and their metabolites.
Takeaway
This study looks at how vitamin D and gut bacteria might affect early puberty in kids, suggesting that taking vitamin D could help.
Methodology
A systematic search of the PubMed database was conducted to evaluate the literature on the interplay between CPP, vitamin D, and gut microbiota.
Limitations
The evidence on the interaction between vitamin D deficiency, gut microbiota, and sexual development remains limited.
Digital Object Identifier (DOI)
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