Apolipoprotein M Levels and HBV Infection
Author Information
Author(s): Gu Jin-Gang, Zhu Cheng-liang, Cheng Duo-zhi, Xie Yan, Liu Fang, Zhou Xin
Primary Institution: Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University
Hypothesis
The study aims to determine the correlation between HBV infection and ApoM expression.
Conclusion
Raised ApoM levels in HBV infection may suppress HBV replication, acting as a protective mechanism.
Supporting Evidence
- ApoM levels were 27 percent higher in the sera of HBV-infected patients compared to healthy individuals.
- HBV infection significantly increased ApoM promoter activity and mRNA expression.
- ApoM overexpression led to a more than threefold decrease in HBV protein levels.
Takeaway
When people get infected with hepatitis B, a protein called ApoM goes up, which helps to stop the virus from making more copies of itself.
Methodology
Serum ApoM levels were measured by ELISA, and ApoM mRNA expression was determined by RT-PCR.
Limitations
The study does not confirm whether ApoM can protect against HBV infection in vivo.
Participant Demographics
126 chronic HBV-infected patients and 118 healthy individuals.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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