Sex-Dependent Imprinting Effects in Mice
Author Information
Author(s): Hager Reinmar, Cheverud James M, Leamy Larry J, Wolf Jason B
Primary Institution: University of Manchester
Hypothesis
Do genomic imprinting effects on complex traits in mice depend on the sex of the individual?
Conclusion
The study found that genomic imprinting effects can vary by sex, revealing new candidate imprinted loci that may be missed in pooled analyses.
Supporting Evidence
- The study identified 13 loci on 11 chromosomes with significant sex-dependent imprinting effects.
- Eight loci showed imprinting effects in males, while six showed effects in females.
- The absence of an imprinting effect in one sex does not indicate inactivity of the locus in that sex.
Takeaway
This study shows that some genes in mice work differently depending on whether the mouse is male or female, which can help us understand how traits are passed down from parents.
Methodology
The study used a genome-scan approach to identify loci affecting growth and body composition traits in an intercross of two mouse strains.
Limitations
The predictions about the evolution of sex-dependent imprinting effects could not be fully supported, indicating a need for further research.
Participant Demographics
The study involved F3 generation mice from an intercross between Large (LG/J) and Small (SM/J) inbred strains.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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