Original Antigenic Sin and Pandemic (H1N1) 2009
2010
Original Antigenic Sin and Pandemic (H1N1) 2009
publication
Evidence: moderate
Author Information
Author(s): Amesh A. Adalja, D.A. Henderson
Primary Institution: University of Pittsburgh Medical Center
Hypothesis
Are older persons protected from infection with the pandemic (H1N1) 2009 virus due to prior exposure to influenza viruses?
Conclusion
Older adults may have partial protection from severe disease caused by the pandemic (H1N1) 2009 virus due to original antigenic sin.
Supporting Evidence
- Data from the CDC showed that approximately two thirds of older persons have evidence of immunity to pandemic (H1N1) 2009 virus.
- Previous studies indicated that vaccination directed toward influenza strains distinct from childhood viruses boosted immune responses to those childhood viruses.
- Evidence from more recent studies largely supported the veracity of original antigenic sin.
Takeaway
The study suggests that older people might be less likely to get sick from the new flu because they had similar flus when they were younger.
Participant Demographics
Older adults and various age cohorts.
Digital Object Identifier (DOI)
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