Effectiveness of DMSO and MSM for Knee Osteoarthritis Pain
Author Information
Author(s): Sarah Brien, Phil Prescott, George Lewith
Primary Institution: University of Southampton
Hypothesis
Do dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) effectively reduce pain in knee osteoarthritis?
Conclusion
The study found that DMSO and MSM do not significantly reduce pain in knee osteoarthritis compared to placebo.
Supporting Evidence
- DMSO and MSM showed no significant clinical effectiveness in reducing knee pain.
- Two studies showed statistically significant pain reduction, but it was not clinically relevant.
- Current evidence suggests that these supplements are not effective for knee osteoarthritis.
Takeaway
This study looked at two supplements, DMSO and MSM, to see if they help with knee pain from arthritis. It turns out they don't really work better than a sugar pill.
Methodology
A meta-analysis of randomized controlled trials assessing the efficacy of DMSO and MSM in treating knee osteoarthritis pain.
Potential Biases
Potential publication bias was noted due to the variability in results among the studies.
Limitations
Only three trials were included, and there were concerns about inadequate treatment duration and dosing.
Participant Demographics
Patients with knee osteoarthritis, average age between 56 to 62 years.
Statistical Information
P-Value
0.043
Confidence Interval
−0.49 to 13.17
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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